Alendronate-Induced Esophagitis: Possible Pathogenic Role of Hypersensitivity to Alendronate
نویسندگان
چکیده
منابع مشابه
Alendronate-induced esophagitis in an elderly woman.
Ingestion of alendronate sodium (Fosamax) had been reported to sometimes cause erosive or ulcerative esophagitis. Despite its widespread use and several case reports describing the clinical and endoscopic presentation, there has been limited discussion on the histologic appearances of the esophagitis caused by the medication. Here we describe one case of an elderly woman who presented with alen...
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BACKGROUND Alendronate, an aminobisphosphonate and a selective inhibitor of osteoclast-mediated bone resorption, is used to treat osteoporosis in postmenopausal women and Paget's disease of bone. Aminobiphosphonates can irritate the upper gastrointestinal mucosa. METHODS We describe three patients who had severe esophagitis shortly after starting to take alendronate and also analyze adverse e...
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The title compound {sys-tematic name: bis(μ(2)-dihydrogen 4-aza-niumyl-1-hy-droxy-butane-1,1-di-phos-pho-n-ato)bis-[aqua-(dihydrogen 4-aza-nium-yl-1-hy-droxy-butane-1,1-diphospho-n-ato)nickel(II)] dihydrate}, [Ni(2)(C(4)H(12)NO(7)P(2))(4)(H(2)O)(2)]·2H(2)O, was synthesiized under hydro-thermal conditions. Its structure is isotypic with the Co(II) analogue. The crystal structure is built up from...
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BACKGROUND Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture. METHODS We performed a randomized, double-placebo, double-blind clinical trial of 18 months' duration among patients with a rheumatic disease who were starting glucocorticoids at a daily dose that was equivalent to at least 7.5 mg of prednisone. A ...
متن کاملAlendronate as an effective countermeasure to disuse induced bone loss.
Microgravity, similar to disuse immobilization on earth, causes rapid bone loss. This loss is believed to be an adaptive response to the reduced musculoskeletal forces in space and occurs gradually enough that changes occurring during short duration space flight are not a concern. Bone loss, however, will be a major impediment for long duration missions if effective countermeasures are not deve...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2008
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.47.1457